Cover
Volume 5, Issue 4 (2025)
Cover Picture: This review discusses how neurodegenerative diseases (like Alzheimer’s and Parkinson’s) and metabolic disorders (like obesity and type 2 diabetes) are linked through shared aging-related mechanisms. The authors show that the twelve hallmarks of aging—such as mitochondrial dysfunction, chronic inflammation, and impaired autophagy—play a key role in both types of disease.
Targeting these common mechanisms with strategies like exercise, intermittent fasting, NAD+ boosters, senolytics, or mitochondrial therapies may help prevent or treat both conditions at once, extend healthspan, and reduce the burden of age-related diseases. The review emphasizes the need for better biomarkers, systems biology approaches, and combination therapies to translate these insights into effective treatments.
Targeting these common mechanisms with strategies like exercise, intermittent fasting, NAD+ boosters, senolytics, or mitochondrial therapies may help prevent or treat both conditions at once, extend healthspan, and reduce the burden of age-related diseases. The review emphasizes the need for better biomarkers, systems biology approaches, and combination therapies to translate these insights into effective treatments.
