All Articles

Targeting the hypoxia signaling pathway with nanomedicine to reverse immunotherapy resistance

Cryptotanshinone differentially induces cell death in ATP6V0D1-deficient pancreatic cancer cells

Resistance signatures manifested in early drug response across cancer types and species

New advances in understanding the mechanisms and treatment challenges of ALK-targeted therapy resistance in lung cancer

ROS1 mutations promote an immunosuppressive tumor microenvironment via MYC to confer immune evasion in head and neck cancer

IRE1α modulates M1 oncolytic virus sensitivity via ER stress regulation in bladder cancer

Corosolic acid increases the therapeutic effect of cisplatin on gastric cancer by regulating Gpx4-dependent ferroptosis

Lactylation: a novel driver of drug resistance in the tumor microenvironment

Effects of FAP⁺ cancer-associated fibroblasts on anti-PD-1 immunotherapy and CD4⁺ T cell polarization in gastric cancer

Super-enhancer inhibitors THZ2 and JQ1 reverse temozolomide resistance in glioblastoma by suppressing SE-driven SOX9 expression

Decoding breast cancer treatment resistance through genetic, epigenetic, and immune-regulatory mechanisms: from molecular insights to translational perspectives

CF10/LV overcomes acquired resistance to 5-FU/LV in colorectal cancer cells through downregulation of the c-Myc/ABCB5 axis

The next frontier in antibody-drug conjugates: challenges and opportunities in cancer and autoimmune therapy

Interactions between tumor microenvironment and resistance to transarterial and systemic treatments for HCC

Modeling methods of different tumor organoids and their application in tumor drug resistance research

Integrated multi-omics profiling of immune microenvironment and drug resistance signatures for precision prognosis in prostate cancer

MicroRNA-mediated autophagy regulation in thyroid cancer drug resistance

Antibody-drug conjugates in breast cancer: current resistance mechanisms and future combination strategies