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Figure 2. Proposed therapeutic interventions targeting the tumor metabolism-ferroptosis-TAM framework. This figure depicts the proposed mechanisms of action and potential therapeutic outcomes of ferroptosis inducers, metabolic inhibitors, GPX4/SLC7A11 inhibitors, iron-based therapies, lipid-peroxidation enhancement, TAM-directed therapy, immune checkpoint blockade (ICB), and targeted nano-delivery systems within the tumor microenvironment (TME). Although these interventions may enhance antitumor immunity, CD8⁺ T-cell infiltration, antigen presentation, and suppression of tumor growth and metastasis, they may also cause immune-cell ferroptosis, systemic toxicity, compensatory resistance, or immunosuppressive TAM reprogramming. Green dashed arrows indicate potential therapeutic benefits, whereas red dashed arrows indicate possible adverse, resistance-associated, or context-dependent effects. TAM: Tumor-associated macrophage; ROS: fatty acid oxidation; HIF-1α: hypoxia-inducible factor-1α.