fig5

Figure 5. Reprogramming senescent cell function and the senescent TME to reverse immune evasion. (A) Senomorphic strategies suppress the deleterious effects of STCs by targeting key SASP-regulating pathways, including cGAS-STING, JAK-STAT, and NF-κB signaling, or by using neutralizing antibodies against specific SASP components. (B) Targeting senescent stromal and immune populations, including senescent CAFs and T cells, using senolytic or senomorphic approaches to remodel the senescent TME.