fig4

Figure 4. Mutational landscape and co-expression network of LGR6 in prostate cancer. (A) LGR6 expression is independent of its mutation status. (B) Low mutation rate of LGR6 in TCGA-PRAD cohort. (C) Differential mutation burden of 13 genes between LGR6 high/low groups. (D) Weak correlation between LGR6 and PD-L1 expression (Pearson’s correlation test). (E) Positive correlation between LGR6 and the 13-gene signature (Pearson’s correlation test). (F) Pan-cancer correlation of LGR6 with RNA modification genes, strongest in PRAD.