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Figure 3. LGR6 is downregulated in prostate cancer associated with promoter hypermethylation. (A) Medium LGR6 protein staining in normal prostate tissue. (B) LGR6 mRNA expression (nTPM) in normal prostate tissues. (C) Weak LGR6 protein staining in prostate cancer tissue. (D) Predominant LGR6 isoforms in TCGA prostate cancer data. (E) Predominant LGR6 isoforms in normal prostate tissue (GTEx). (F) Promoter hypermethylation of LGR6 in prostate cancer (TCGA). (G) Differentially methylated regions between cancer and adjacent tissues. Immunohistochemistry images (A-C) were obtained from the human protein atlas (HPA) at 20× magnification, corresponding to a scale bar of 50 μm. This figure was generated by the authors based on publicly available data from TCGA, GEO and HPA; no additional patient samples were used.