fig5

Figure 5. XIAP knockdown enhances obatoclax-mediated TRAIL-induced apoptosis. (A) XIAP expression levels were determined by Western blot analysis after incubation with 0.5 μM or 2 μM for A549 and SW1573 cells, respectively, at the indicated times. (B) XIAP-silenced A549 and SW1573 cells were exposed to concurrent treatment with 50 ng/mL TRAIL and 0.5 and 2 μM obatoclax for SW1573 and A549, respectively. Western blots show one representative result from at least three separate experiments. Values are means ± SEM of at least three separate experiments. Statistics, compared to ut (untreated), ^#P < 0.01; *P < 0.001.