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Figure 4. CHST14 is related to drug sensitivity and immune cell infiltration. (A) Relationship between CHST14 and drug sensitivity. Using the R package “pRRophetic”, the Genomics of Drug Sensitivity in Cancer (GDSC) database was accessed to predict the chemotherapeutic response for each sample. Default parameters were used for the prediction, and the half-maximal inhibitory concentration (IC50) of each sample was estimated via ridge regression. The association between CHST14 expression and the drugs SN-38, paclitaxel, 5-fluorouracil, YM155, QL-VIII-58, BEZ235, Docetaxel, and Doxorubicin was analyzed. (B) CHST14 and immune cell infiltration. The TIMER algorithm was used to estimate levels of immune cell infiltration. Correlations between CHST14 expression and B cells, CD4+ T cells, CD8+ T cells, neutrophils, macrophages, and myeloid dendritic cells were analyzed. GDSC: Genomics of drug sensitivity in cancer; IC50: half-maximal inhibitory concentration.