Volume 6, Issue 1 (2026) – 16 articles
Cover Picture: This review summarizes sex differences in metabolic dysfunction-associated steatotic liver disease (MASLD), covering epidemiology, pathogenesis, clinical progression, and treatment responses. Evidence suggests that MASLD is more prevalent in males, while the protective effect in females declines after menopause, highlighting the importance of sex and reproductive status in disease development. Sex influences MASLD risk through multiple mechanisms, including fat distribution, hormone signaling, immune regulation, and other metabolic pathways, while reproductive factors and exogenous hormone exposure further shape risk profiles. The article also discusses MASLD in pregnancy and sex-specific responses to lifestyle and pharmacological interventions, and outlines future research directions.
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