Topic: Breast Cancer Metastasis

Although metastasis is the most lethal characteristic of breast cancer, our understanding of the molecular mechanisms that govern this event remains incomplete. The metastatic cascade is a highly complex and inefficient process that is subject to regulation by a host of intrinsic and extrinsic cellular mechanisms. The rapid development of powerful new technologies and models to study the breast cancer metastasis has greatly expanded our appreciation of the complexities associated with this last frontier of cancer biology. The Journal of Cancer Metastasis and Treatment will produce a Special Issue focused on breast cancer metastasis and its treatment. Included amongst the topics within the scope of this Special Issue on Breast Cancer Metastasis are:

• Mechanisms of EMT programs and cellular plasticity, including breast cancer stem cells
• Mechanisms of metastatic dormancy
• Mechanisms of pro-survival and anti-apoptotic and/stress signals
• Role of noncoding RNA and epigenetics in driving metastatic progression
• Impact of the tumor microenvironment and metastatic niche, including tumor-associated fibroblasts, macrophages, and mesenchymal stem cells
• Role of the immune system and immune modulators
• Novel technologies and models to detect and study breast cancer metastases
• Therapeutic targeting of breast cancer metastasis

Questions related to this Special Issue should be directed to the Issue Editor, Dr. William Schiemann (William.Schiemann@jcmtjournal.com). Submissions will be accepted starting from July 20 for publication of the Special Issue in Winter 2018/Spring 2019.

30 Apr 2019