Topic: Pathophysiology of Gynecologic Cancers

Gynecologic cancers include five primary types: cervical, ovarian, uterine (endometrial), vaginal, and vulvar. Additionally, there exists a very rare type known as fallopian tube cancer. Among these gynecologic cancers, only cervical cancer benefits from screening tests that enable early detection, facilitating more effective treatment.

The approach to treating gynecologic cancer varies depending on the specific type, its stage of progression, and the patient’s reproductive considerations.

In cases where the disease has reached an advanced stage, surgery typically serves as the main treatment option. Hysterectomy is a common procedure for patients with cervical, uterine, and ovarian cancers. Radiation therapy or chemotherapy can also be employed to halt further cancer spread. However, chemo- and radio-resistance often occurs, worsening the outcome of the disease.

For these reasons, the identification of early markers for diagnosing these pathologies and the discovery of new therapeutic targets are crucial to improving both treatment strategies and patient outcomes.

In this Special Issue of Journal of Cancer Metastasis and Treatment, we invite original studies that delve into the molecular mechanisms involved in gynecological cancer progression and metastasis in order to find or suggest possible molecular targets to enhance the therapeutic interventions and improve the prognosis for individuals with these conditions.

In addition, studies focused on early detection, diagnosis, and monitoring of response to therapy are also welcomed.

Cervical, endometrial, uterine, ovarian, vaginal, vulvar, cancer, treatment, chemotherapy, radiotherapy

31 May 2024