fig8

Figure 8. Biodegradable OMIECs for transient bioelectronics. (A) Left: Molecular structure of P(CL-co-AVL)-g-O3HT and optical photographs showing the biodegradation behavior of the P(CL-co-AVL)-LD-g-O3HT-30 films in water, 2 M TFA, and 2 M NaOH at 0, 3, and 7 days. Right: Drain current curves of the P(CL-co-AVL)-LD-g-O3HT-30-based OECT device before and after degradation in 2 M aqueous NaOH using PBS as the gate electrolyte and an Ag/AgCl gate electrode (V_ds = 0-0.8 V, V_g = -0.6~0.6 V). Reproduced with permission from Ref.^[137]. Copyright 2024, Royal Society of Chemistry; (B) Left: Molecular structure of PEDOT:Sacran, illustrating charge compensation between the positively charged PEDOT backbone and the negatively charged groups of Sacran. Right: Schematic representation of a flexible PET-based OECT employing PEDOT:Sacran as the channel material. Reproduced with permission from Ref.^[38] under the CC BY license; (C) Left: Schematic illustration of an OECT-based artificial synapse employing a fully biodegradable OMIEC as the channel material. The OMIEC contains acid-hydrolyzable imine linkages and yields biocompatible degradation products upon hydrolysis. Right: The graph illustrates spike-duration-dependent plasticity behavior of i-3gTIT devices induced by spike durations ranging from 0.1 to 1.0 s, exhibiting a clear transition from volatile to non-volatile memory states (V_GS,Pre = -1.5 V, V_DS = -0.5 V). Reprinted with permission from Ref.^[46]. Copyright 2025, John Wiley & Sons. OMIECs: Organic mixed ionic–electronic conductors; O3HT: oligo(3-hexylthiophene); TFA: trifluoroacetic acid; OECT: organic electrochemical transistor; PBS: phosphate-buffered saline; PEDOT: poly(3,4-ethylenedioxythiophene); PET: poly(ethylene terephthalate); BOPLA: biaxially oriented poly(lactic acid); EPSC: excitatory postsynaptic current.