REFERENCES
1. Li, H.; Zhang, D.; Bao, P.; et al. Recent advances in functional hydrogels for treating dental hard tissue and endodontic diseases. ACS. Nano. 2024, 18, 16395-412.
2. Xu, S.; Hu, B.; Dong, T.; et al. Alleviate periodontitis and its comorbidity hypertension using a nanoparticle-embedded functional hydrogel system. Adv. Healthc. Mater. 2023, 12, e2203337.
3. Gong, J.; Wang, S.; Liu, J.; et al.
4. Zhang, F.; Wu, C.; Zhou, Z.; et al. Blue-light-activated nano-TiO2@PDA for highly effective and nondestructive tooth whitening. ACS. Biomater. Sci. Eng. 2018, 4, 3072-7.
5. Gao, J.; Wang, J.; Yue, X.; et al. Photostable aggregation-induced emission photosensitizer nanoparticle/hyaluronic acid hydrogel for efficient photodynamic tooth bleaching. ACS. Appl. Nano. Mater. 2022, 5, 5944-51.
6. Li, Q.; Liu, J.; Xu, Y.; et al. Fast cross-linked hydrogel as a green light-activated photocatalyst for localized biofilm disruption and brush-free tooth whitening. ACS. Appl. Mater. Interfaces. 2022, 14, 28427-38.
7. Cheng, K.; She, P.; Wang, H.; et al. A bio-inspired versatile free-standing membrane for oral cavity microenvironmental monitoring and remineralization to prevent dental caries. Mater. Horiz. 2023, 10, 512-23.
8. Wang, D.; Deng, J.; Deng, X.; Fang, C.; Zhang, X.; Yang, P. Controlling enamel remineralization by amyloid-like amelogenin mimics. Adv. Mater. 2020, 32, e2002080.
9. He, J.; Yang, J.; Li, M.; et al. Polyzwitterion manipulates remineralization and antibiofilm functions against dental demineralization. ACS. Nano. 2022, 16, 3119-34.
10. Siddiqui, Z.; Sarkar, B.; Kim, K. K.; et al. Angiogenic hydrogels for dental pulp revascularization. Acta. Biomater. 2021, 126, 109-18.
11. Zheng, L.; Liu, Y.; Jiang, L.; et al. Injectable decellularized dental pulp matrix-functionalized hydrogel microspheres for endodontic regeneration. Acta. Biomater. 2023, 156, 37-48.
12. Li, M.; Tian, J.; Yu, K.; et al. A ROS-responsive hydrogel incorporated with dental follicle stem cell-derived small extracellular vesicles promotes dental pulp repair by ameliorating oxidative stress. Bioact. Mater. 2024, 36, 524-40.
13. Liang, Z.; Li, J.; Lin, H.; et al. Understanding the multi-functionality and tissue-specificity of decellularized dental pulp matrix hydrogels for endodontic regeneration. Acta. Biomater. 2024, 181, 202-21.
14. Chung, Y. L.; Lee, J. J.; Chien, H. H.; Chang, M. C.; Jeng, J. H. Interplay between diabetes mellitus and periodontal/pulpal-periapical diseases. J. Dent. Sci. 2024, 19, 1338-47.
15. Wang, Y.; Zhu, J.; Zhou, Y.; Tang, Y.; Huang, C. Exploring relationships between circulating interleukins and pulp and periapical diseases: a bidirectional mendelian randomization study. J. Endod. 2025, 51, 132-9.
16. Ribeiro, J. S.; Bordini, E. A. F.; Ferreira, J. A.; et al. Injectable MMP-responsive nanotube-modified gelatin hydrogel for dental infection ablation. ACS. Appl. Mater. Interfaces. 2020, 12, 16006-17.
17. Robberecht, L.; Delattre, J.; Meire, M. Isthmus morphology influences debridement efficacy of activated irrigation: a laboratory study involving biofilm mimicking hydrogel removal and high-speed imaging. Int. Endod. J. 2023, 56, 118-27.
18. Wang, Z.; Wei, H.; Huang, Y.; Wei, Y.; Chen, J. Naturally sourced hydrogels: emerging fundamental materials for next-generation healthcare sensing. Chem. Soc. Rev. 2023, 52, 2992-3034.
19. Yin, Y.; Shuai, F.; Liu, X.; Zhao, Y.; Han, X.; Zhao, H. Biomaterials and therapeutic strategies designed for tooth extraction socket healing. Biomaterials 2025, 316, 122975.
20. Reis, A.; Tay, L. Y.; Herrera, D. R.; Kossatz, S.; Loguercio, A. D. Clinical effects of prolonged application time of an in-office bleaching gel. Oper. Dent. 2011, 36, 590-6.
21. Kielbassa, A. M.; Maier, M.; Gieren, A. K.; Eliav, E. Tooth sensitivity during and after vital tooth bleaching: a systematic review on an unsolved problem. Quintessence. Int. 2015, 46, 881-97.
22. Huang, Y.; Liu, Y.; Shah, S.; et al. Precision targeting of bacterial pathogen via bi-functional nanozyme activated by biofilm microenvironment. Biomaterials 2021, 268, 120581.
23. Naha, P. C.; Liu, Y.; Hwang, G.; et al. Dextran-coated iron oxide nanoparticles as biomimetic catalysts for localized and pH-activated biofilm disruption. ACS. Nano. 2019, 13, 4960-71.
24. Jia, B.; Zhang, B.; Li, J.; et al. Emerging polymeric materials for treatment of oral diseases: design strategy towards a unique oral environment. Chem. Soc. Rev. 2024, 53, 3273-301.
25. Chen, X.; Huang, N.; Wang, D.; et al. Sulfated chitosan-modified CuS nanocluster: a versatile nanoformulation for simultaneous antibacterial and bone regenerative therapy in periodontitis. ACS. Nano. 2024, 18, 14312-26.
26. Xiao, M.; Zhang, X.; Luo, Y.; Xie, R.; Tao, K.; Wu, J. Engineering hydrogel-based conformal epidermal electrodes for human-machine interaction. Soft. Sci. 2025, 5, 40.
27. You, M.; Guo, Y.; Yu, H.; et al. Polyphenol-enhanced wet adhesive hydrogel with synergistic mechanical activation and ROS scavenging for accelerating diabetic wound healing. Chem. Eng. J. 2024, 500, 157103.
28. Deng, D.; Liang, L.; Su, K.; et al. Smart hydrogel dressing for machine learning-enabled visual monitoring and promote diabetic wound healing. Nano. Today. 2025, 60, 102559.
29. Wen, N.; Li, S.; Jiang, H.; et al. Bio-inspired self-healing hydrogel for fast hemostasis and accelerated wound healing of gastric ulcers. Adv. Funct. Mater. 2025, 35, 2411959.
30. Zhang, D.; Zhou, Y.; Mao, Y.; et al. Highly antifreezing thermogalvanic hydrogels for human heat harvesting in ultralow temperature environments. Nano. Lett. 2023, 23, 11272-9.
31. Liu, L.; Zhang, D.; Bai, P.; et al. Fatigue-resistant and super-tough thermocells. Nat. Commun. 2025, 16, 1963.
32. Yang, Q.; Sun, X.; Ding, Q.; et al. An ATP-responsive metal-organic framework against periodontitis via synergistic ion-interference-mediated pyroptosis. Natl. Sci. Rev. 2024, 11, nwae225.
33. Fang, X.; Wang, J.; Ye, C.; et al. Polyphenol-mediated redox-active hydrogel with H2S gaseous-bioelectric coupling for periodontal bone healing in diabetes. Nat. Commun. 2024, 15, 9071.
34. Dos Santos, D. M.; Moon, J. I.; Kim, D. S.; et al. Hierarchical chitin nanocrystal-based 3D printed dual-layer membranes hydrogels: a dual drug delivery nano-platform for periodontal tissue regeneration. ACS. Nano. 2024, 18, 24182-203.
35. Ma, Y.; Yang, X.; Chen, Y.; et al. Biomimetic peridontium patches for functional periodontal regeneration. Adv. Healthc. Mater. 2023, 12, e2202169.
36. Bai, L.; Yang, M.; Wu, J.; et al. An injectable adhesive hydrogel for photothermal ablation and antitumor immune activation against bacteria-associated oral squamous cell carcinoma. Acta. Biomater. 2024, 186, 229-45.
37. Chen, L.; Tang, S.; Zhang, J.; et al. Prussian blue nanohybridized multicellular spheroids as composite engraftment for antioxidant bone regeneration and photoacoustic tomography. ACS. Nano. 2024, 18, 24770-83.
38. He, G.; Xian, Y.; Lin, H.; et al. An injectable and coagulation-independent Tetra-PEG hydrogel bioadhesive for post-extraction hemostasis and alveolar bone regeneration. Bioact. Mater. 2024, 37, 106-18.
39. Ma, S.; Li, Y.; Yao, S.; et al. A deformable SIS/HA composite hydrogel coaxial scaffold promotes alveolar bone regeneration after tooth extraction. Bioact. Mater. 2025, 46, 97-117.
40. Xing, Q.; Zhen, L.; Zhou, X.; et al. Cohesion regulation of polyphenol cross-linked hydrogel adhesives: from intrinsic cross-link to designs of temporal responsiveness. Adv. Funct. Mater. 2025, 35, 2414294.
41. Li, M.; Su, Z.; Zhu, J.; et al. Clinically oriented oral environment-triggered underwater adhesives for root caries treatment through dentinal tubule occlusion and remineralization. ACS. Appl. Mater. Interfaces. 2025, 17, 16576-89.
42. Liu, S.; Wang, Y. N.; Ma, B.; Shao, J.; Liu, H.; Ge, S. Gingipain-responsive thermosensitive hydrogel loaded with SDF-1 facilitates in situ periodontal tissue regeneration. ACS. Appl. Mater. Interfaces. 2021, 13, 36880-93.
43. Wu, D.; Wang, P.; Wu, Q.; et al. Preparation and characterization of Bomidin-loaded thermosensitive hydrogel for periodontal application. J. Mater. Res. 2022, 37, 3021-32.
44. Hao, M.; Zhang, D.; Wang, W.; et al. HAp thermosensitive nanohydrogel cavities act as brood pouches to incubate and control-release NSCs for rapid spinal cord injury therapy. Adv. Funct. Mater. 2022, 32, 2203492.
45. Chen, L.; Peng, M.; Zhou, J.; et al. Supramolecular photothermal cascade nano-reactor enables photothermal effect, cascade reaction, and in situ hydrogelation for biofilm-associated tooth-extraction wound healing. Adv. Mater. 2023, 35, e2301664.
46. Sun, J.; Chen, T.; Zhao, B.; et al. Acceleration of oral wound healing under diabetes mellitus conditions using bioadhesive hydrogel. ACS. Appl. Mater. Interfaces. 2023, 15, 416-31.
47. Zhang, Z.; Zhang, Q.; Gao, S.; Xu, H.; Guo, J.; Yan, F. Antibacterial, anti-inflammatory and wet-adhesive poly(ionic liquid)-based oral patch for the treatment of oral ulcers with bacterial infection. Acta. Biomater. 2023, 166, 254-65.
48. Chen, A.; Deng, S.; Lai, J.; et al. Hydrogels for oral tissue engineering: challenges and opportunities. Molecules 2023, 28, 3946.
49. Qi, Y.; Yang, J.; Chi, Y.; et al. Natural polyphenol self-assembled pH-responsive nanoparticles loaded into reversible hydrogel to inhibit oral bacterial activity. Mol. Biomed. 2022, 3, 28.
50. Liu, M.; Huang, L.; Xu, X.; et al. Copper doped carbon dots for addressing bacterial biofilm formation, wound infection, and tooth staining. ACS. Nano. 2022, 16, 9479-97.
51. Dai, C.; Shi, Z.; Xu, Y.; et al. Wearable multifunctional hydrogel for oral microenvironment visualized sensing coupled with sonodynamic bacterial elimination and tooth whitening. Adv. Healthc. Mater. 2025, 14, e2401269.
52. Deng, S.; Zhang, Y.; Qiao, Z.; et al. Hierarchically designed biodegradable polylactide particles with unprecedented piezocatalytic activity and biosafety for tooth whitening. Biomacromolecules 2023, 24, 797-806.
53. Zhang, H.; Zhu, Y.; Li, Y.; et al. A bifunctional zwitterion-modified porphyrin for photodynamic nondestructive tooth whitening and biofilm eradication. Adv. Funct. Mater. 2021, 31, 2104799.
54. Wang, Y.; Wang, S.; Meng, Y.; et al. Pyro-catalysis for tooth whitening via oral temperature fluctuation. Nat. Commun. 2022, 13, 4419.
55. Gao, W.; Liu, Y.; Li, M.; et al. A drop-by-drop self-assembled all-natural hydrogel as a desensitizer for rapid and enduring management of dentin hypersensitivity. Adv. Healthc. Mater. 2024, 13, e2303153.
56. Zhu, J.; Zhang, M.; Qiu, R.; et al. Hagfish-inspired hydrogel for root caries: a multifunctional approach including immediate protection, antimicrobial phototherapy, and remineralization. Acta. Biomater. 2024, 188, 117-37.
57. Muşat, V.; Anghel, E. M.; Zaharia, A.; et al. A chitosan-agarose polysaccharide-based hydrogel for biomimetic remineralization of dental enamel. Biomolecules 2021, 11, 1137.
58. Zhu, J.; Zhen, L.; Gao, Y.; et al. Bionic wet-adhesive tooth band-aid with bidirectional anchoring to promote dentin remineralization. Chem. Eng. J. 2025, 514, 163314.
59. Soares, D. G.; Bordini, E. A. F.; Swanson, W. B.; de Souza Costa, C. A.; Bottino, M. C. Platform technologies for regenerative endodontics from multifunctional biomaterials to tooth-on-a-chip strategies. Clin. Oral. Investig. 2021, 25, 4749-79.
60. Xie, Z.; Shen, Z.; Zhan, P.; et al. Functional dental pulp regeneration: basic research and clinical translation. Int. J. Mol. Sci. 2021, 22, 8991.
61. Eramo, S.; Natali, A.; Pinna, R.; Milia, E. Dental pulp regeneration via cell homing. Int. Endod. J. 2018, 51, 405-19.
62. Wang, S.; Xing, X.; Peng, W.; et al. Fabrication of an exosome-loaded thermosensitive chitin-based hydrogel for dental pulp regeneration. J. Mater. Chem. B. 2023, 11, 1580-90.
63. Park, E. H.; Park, R.; Seo, J.; Kim, W.; Kim, H. Y.; Shon, W. J. Efficacy of a novel remotely-generated ultrasonic root canal irrigation system for removing biofilm-mimicking hydrogel from a simulated isthmus model. Int. Endod. J. 2023, 56, 765-74.
64. Li, T.; Luo, Y.; Wu, S.; et al. Super-rapid in situ formation of a silver ion-induced supramolecular hydrogel with efficient antibacterial activity for root canal disinfection. ACS. Appl. Mater. Interfaces. 2023, 15, 29854-65.
65. Wang, L.; Sun, L.; Bian, F.; Wang, Y.; Zhao, Y. Self-bonded hydrogel inverse opal particles as sprayed flexible patch for wound healing. ACS. Nano. 2022, 16, 2640-50.
66. Wang, J.; Ren, H.; Liu, Y.; et al. Bioinspired artificial liver system with hiPSC-derived hepatocytes for acute liver failure treatment. Adv. Healthc. Mater. 2021, 10, e2101580.
67. Monteiro, N.; Thrivikraman, G.; Athirasala, A.; et al. Photopolymerization of cell-laden gelatin methacryloyl hydrogels using a dental curing light for regenerative dentistry. Dent. Mater. 2018, 34, 389-99.
68. Xu, F.; Zhang, Q.; Liu, S.; Zhao, Y. Injectable, ROS-scavenging, drug-loaded hydrogel dressings of natural origin for oral postoperative care. Mater. Today. Commun. 2023, 35, 105634.
