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Figure 6. Multifunctional treatment strategies for chronic infected wounds based on metal nanozyme-hydrogel systems. (A) An antibacterial hydrogel integrating ROS scavenging, O₂ generation and NO release eradicates MRSA infection, relieve inflammation and promotes healing in diabetic wounds. Reproduced with permission from Ref.^[108]. Copyright 2022, Elsevier; (B) Schematic diagram of producing H₂O₂ and scavenging ROS. Reproduced with permission from Ref.^[109]. Copyright 2024, Springer; Figure 6B is reproduced from (Pu, C., 2024) under the CC BY-NC-ND license. No modifications were made; (C) Schematic illustration of PdNPs extraction from the traditional Chinese medicine Bletilla striata, preparation of PDAs, and their subsequent microfluidic encapsulation into HAMA hydrogel microcarriers. Reproduced with permission from Ref.^[111]. Copyright 2025, Springer; Figure 6C is reproduced from (Che, J., 2024) under the CC BY-NC-ND license. No modifications were made; (D) PdNP + PDA@HAMA hydrogel microcarriers markedly enhance diabetic wound healing compared with controls, as evidenced by faster wound closure and improved histological regeneration on H&E and Masson’s staining (12 rats each group). Reproduced with permission from Ref.^[111]. Copyright 2025, Springer; Figure 6D is reproduced from (Che, J., 2024) under the CC BY-NC-ND license. No modifications were made; (E) Multifaceted functions of the MZGB hydrogel during diabetic wound healing. Reproduced with permission from Ref.^[112]. Copyright 2025, Elsevier; (F) Dynamic, phase-adaptive regulatory roles of the gel in promoting scarless wound healing. Reproduced with permission from Ref.^[33]. Copyright 2025, Nature. ROS: Reactive oxygen species; MRSA: methicillin-resistant Staphylococcus aureus; NPs: nanoparticles; PDAs: polydopamines; HAMA: hyaluronic acid methacrylate; H&E: Hematoxylin and Eosin; MZGB: Mn-ZIF@GOx/BC; HBPL: hyperbranched poly-L-lysine; PEGMA-GMA-AAm: polyethylene glycol methacrylate - glycidyl methacrylate -acrylamide copolymer; IL: interleukin; CXCL: Chemokine (C-X-C motif) ligand; TNF: tumor necrosis factor; CAT: catalase; SOD: superoxide dismutase; PBS: phosphate buffered saline; HE: Hematoxylin and Eosin; ATP: adenosine triphosphate; MCs: mast cells.