fig5

Figure 5. Tumor microenvironment remodeling and combination therapeutic strategies enabled by metal nanozyme-hydrogel systems. (A) Schematic Illustration of a Photoenzymatic Cascade Therapy (PECT): Carbon Nanodot-Based Hydrogel for Preventing Tumor Recurrence after Surgery; (B) Body weight, tumor volume, and survival curves after different treatments. ^****P < 0.0001; (C) Representative photographs of recurrent tumors after different treatments and H&E and TUNEL staining at the 24th day; (D) Timeline for treatment and recurrence monitoring following tumor resection. This figure quoted with permission from Ref.^[97]. Copyright 2025, American Chemical Society. Cl-FeNCDs: Axially chlorinated single-atom Fe/N-doped carbon nanodots; BSA: bovine serum albumin; CDs@BSA: encapsulation of Cl-FeNCDs in bovine serum albumin yields stable nanocomplexes; PDT: photodynamic; POD: peroxidase; MPO: myeloperoxidase; ROS: reactive oxygen species; GSDME: gasdermin E; CTL: cytotoxic T lymphocyte; DC: dendritic cell; DAMPs: damage-associated molecular patterns; + L: 625 nm light irradiation; H&E: Hematoxylin and Eosin; TUNEL: terminal deoxynucleotidyl transferase dUTP nick end labeling.