fig4

Figure 4. Associations of plasma BCAAs with the circulating proteome. (A) Associations between total BCAA and 1,459 proteins; (B) Associations between individual BCAA (isoleucine, leucine, and valine) and proteins. All models were fully adjusted for covariates. The horizontal dashed line indicates the significance threshold (FDR = 0.05); (C) Overlap of proteins significantly associated with total BCAA and all three individual BCAA species. BCAA: Branched-chain amino acid; FDR: false discovery rate.