fig2

Figure 2. Echocardiographic properties of experimental mice treated with RAGE inhibitor FPS-ZM1 for 4 weeks. (A) M-mode echocardiographic traces from all groups; (B) septal thickness; (C) LV posterior wall thickness; (D) LVESD; (E) LVEDD; (F) Ejection fraction; (G) Fractional shortening; (H) LV mass; (I) Normalized LV mass (LV mass/body weight); (J) Heart weight; (K) Normalized heart weight (Heart weight/body weight); (L) Heart rate. Mean ± SEM, n = 9 mice per group, normal distribution was judged using the Shapiro-Wilk test, all experimental results were evaluated using one-way ANOVA and then Tukey’s post hoc test, ^*P < 0.05 between labeled groups. RAGE: Receptor for AGEs; LV: left ventricular; LVESD: LV end systolic diameter; LVEDD: LV end diastolic diameter; SEM: standard error of the mean; ANOVA: analysis of variance.