fig4

Figure 4. Histopathological spectrum of MASLD and corresponding parameters of the NASH-CRN scoring system. Representative histology and main characteristics of each stage of the disease, including the components of the NAS score (steatosis, lobular inflammation, and hepatocellular ballooning) and the corresponding stage of fibrosis (F0-F4). Micrographs were obtained at ×100 (cirrhosis), ×200 (SS, mild and advanced fibrosis), and ×400 (MASH); scale bars represent 50 µm. Created in BioRender. Ramírez, M. (2026) https://BioRender.com/hthbzdp. SS: Simple steatosis; MASH: metabolic dysfunction-associated steatohepatitis; HSCs: hepatic stellate cells; ECM: extracellular matrix; NAS: NAFLD Activity Score; NASH-CRN: Nonalcoholic Steatohepatitis Clinical Research Network.