fig4

Figure 4. Combined Inflammatory and Angiogenic Signaling in PTC-Derived uEVs. CD31^-/PLVAP⁺/CD144^-/DLL4⁺/MCP-1⁺ uEV levels are elevated in the obese compared to lean subjects, * P < 0.05, t-test. (A). Direct correlations were observed between CD31^-/PLVAP⁺/CD144^-/DLL4⁺/MCP-1⁺ uEV and urinary MCP-1 levels (B) and body weight (C); but not with BMI (D). CD31: cluster of differentiation 31; PLVAP: plasmalemma vesicle-associated protein; CD144: cluster of differentiation 144; MCP-1: monocyte chemoattractant protein-1; DLL4: delta-like-ligand-4; BMI: body mass index; PTC: peritubular capillary; uEV: urinary extracellular vesicle.