fig1

Figure 1. Correlations between in-patient changes in insulin sensitivity indices and THS indices during an 8-week 5:2 IF intervention after adjusting for age, sex, and EWL. (A) ΔTFQI and Δfasting insulin; (B) ΔTFQI and ΔHOMA-IR; (C) ΔTFQI and ΔAdipo-IR; (D) ΔTT4RI and Δfasting insulin; (E) ΔTT4RI and ΔHOMA-IR; (F) ΔTT4RI and ΔAdipo-IR; (G) ΔTSHI and Δfasting insulin; (H) ΔTSHI and ΔHOMA-IR; (I) ΔTSHI and ΔAdipo-IR; (J) ΔFT3/FT4 and Δfasting insulin; (K) ΔFT3/FT4 and ΔHOMA-IR; (L)ΔFT3/FT4 and ΔAdipo-IR. Δ shows the post-intervention differences from baseline. THS: Thyroid hormone sensitivity; IF: intermittent fasting; EWL: excessive weight loss; TFQI: thyroid feedback quantile-based index; HOMA-IR: homeostatic model assessment of insulin resistance; Adipo-IR: adipose tissue insulin resistance index; TT4RI: thyrotroph thyroxine resistance index; TSHI: thyroid-stimulating hormone index; FT3: free triiodothyronine; FT4: free thyroxine.