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fig6

From:  Bilirubin ameliorates metabolic dysregulation by targeting the HSP90β/SREBPs signaling axis to improve insulin resistance and mitigate ectopic lipid deposition
Bilirubin ameliorates metabolic dysregulation by targeting the HSP90β/SREBPs signaling axis to improve insulin resistance and mitigate ectopic lipid deposition

Figure 6. Bilirubin binds specifically to HSP90β. (A) Computational docking analysis (PDB: 3PRY) revealed that bilirubin localizes within the middle domain of HSP90β (residues 312-439), forming hydrogen bonds with TRP-312, ARH-338, ALA-339, PRO-340, and ARG-378; (B) MST assays confirmed the direct binding interaction between bilirubin and HSP90β.

Metabolism and Target Organ Damage
ISSN 2769-6375 (Online)
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