fig1
Figure 1. Pathways involved in the metabolism of homocysteine and role of cobalamin (vitamin B12), pyridoxine (vitamin B6), folic acid, and betaine. SAM: S-adenosylmethionine; SAH: S-adenosylhomocysteine; PE: phosphatidylethanolamine; PC: phosphatidylcholine; PEMT: phosphatidylethanolamine N-methyltransferase; BHMT: betaine-homocysteine methyltransferase; CBS: cystathionine β-synthase; THF: tetrahydrofolate; MethylTHF: 5-methyltetrahydrofolate; PON1: paraoxonase 1; PON3: paraoxonase 3.