fig1

Figure 1. Analytical workflow. A four-step analytical workflow for investigating the genetic relationship between AP and T2D. The four steps span genetic correlation, pleiotropic SNP identification, gene annotation with network and functional enrichment analyses, and causal relationship assessment. The figure was created by BioRender.com (https://BioRender.com/5brb66n). AP: Acute pancreatitis; T2D: type 2 diabetes; SNP: single-nucleotide polymorphism; LDSC: linkage disequilibrium score regression; LD: linkage disequilibrium; PLACO: pleiotropy analysis under the composite null hypothesis; PPI: protein-protein interaction; MR: Mendelian randomization.