fig3

Figure 3. Effects of Gc inhibition on hallmarks of (A) type 2 diabetes and (B) obesity in high fat diet-fed mice, based on previous studies^[130,134]. GcKO: Gc knockout mice. WT: Wild-type mice. HFD: High-fat diet. DEXA: dual-energy X-ray absorptiometry. Created in BioRender. Gill, R. (2026) https://BioRender.com/buhul0t. Gc: Group-specific component; GcKO: Gc knockout mice; WT: wild-type mice; HFD: high-fat diet; DEXA: dual-energy X-ray absorptiometry; Aldh1a3: aldehyde dehydrogenase 1 family member A3; Pck1: phosphoenolpyruvate carboxykinase 1; G6pase: glucose-6-phosphatase; Fbp1: fructose-1,6-bisphosphatase 1.