fig2

Figure 2. Overview of MASLD/MASH pathogenesis. Schematic illustration of the central role played by insulin resistance in connecting extra-hepatic determinants with intrahepatic pathomechanism. The former primarily involves adiposopathy, defined as an expanded, inflamed and dysfunctional adipose tissue, and gut dysbiosis, namely decreased intestinal bacteria diversity. The latter comprises increased de novo lipogenesis and activated proinflammatory and pro-fibrotic pathways determining the progression from MASLD to MASH. This original illustration was generated using Servier Medical ART (SMART) and is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0), utilizing data notions from^[10,13,18]. MASLD: Metabolic dysfunction-associated steatotic liver disease; MASH: metabolic dysfunction-associated steatohepatitis.