fig4

Figure 4. Comparison of neuroimaging and hepatic imaging characteristics of WD and HCs. (A) Difference in liver R₂ values between WD and HC; (B) Difference in brain QSM value in WD and HC; (C) Difference in Brain volumes in WD and HC. “R₂” denotes the quantified iron deposition measured within the ROIs in the eight Couinaud liver segments. “Brain iron” indicates the assessment of iron deposition in specific brain regions using QSM; (D) The ROC curves and AUC values illustrating the diagnostic performance of the selected variables using LASSO regression to distinguish between WD and HCs. Results are expressed as mean ± SEM. ^****P < 0.0001; ^***P < 0.001; ^**P < 0.01; ^*P < 0.05. WD: Wilson’s disease; HCs: healthy controls; QSM: quantitative susceptibility mapping; ROIs: regions of interest; SEM: standard error of measurement; ROC: receiver operating characteristic; AUC: area under the curve; LASSO: Least Absolute Shrinkage and Selection Operator.