fig1

Figure 1. The association effects of PRS with incident cirrhosis among individuals with MASLD. (A) standardized cumulative cirrhosis rates in Q1 (lowest quintile), Q2 (2 to 4 quintile), and Q3 (highest quintile) genetic risk groups; (B) the association effects of PRS with incident cirrhosis risk. HRs and 95%CIs were estimated with adjustment for age, sex, ethnicity, Townsend deprivation index, body mass index, alcohol status, smoking status, physical activity, history of hypertension, history of diabetes, and history of heart disease. MASLD: Metabolic dysfunction-associated steatotic liver disease; 95%CI: 95% confidence interval; PRS: polygenic risk score; HR: hazard ratio.