fig2

Figure 2. YH mitigates diabetic nephropathy in db/db mice. (A) Blood glucose measurements in eight experimental groups (n = 8 per group): db/m control, db/m + YH (2.5, 5, and 10 mg/kg), and db/db mice with or without YH treatment (2.5, 5, and 10 mg/kg) administered daily by gavage for eight weeks; (B) Body weight comparisons between control and diabetic mice with or without YH intervention; (C) ACR evaluated from urine samples collected every four weeks; (D) Terminal BUN levels measured from orbital sinus samples at study conclusion. ^*P < 0.05; ^**P < 0.01 compared to untreated db/db group. YH: Yohimbine; ACR: albumin-to-creatinine ratio; BUN: blood urea nitrogen.