fig2

Figure 2. Evidence-gated interpretation and mechanism-matched therapeutic testing for PLA2G2A. (A) Compartment annotation: four essential domains; (B) Two orthogonal evidence axes(not hierarchical); (C) Mechanism-matched therapeutic strategies (hypothesis-driven). EVs: Extracellular vesicles; AA: arachidonic acid; sPLA2-IIA: group IIA secreted phospholipase A2; COX: cyclooxygenase; LOX: lipoxygenase; ECM: extracellular matrix; PLA2R1: phospholipase A2 receptor 1; HSPGs: heparan sulphate proteoglycans; EGFR: epidermal growth factor receptor; HER: human epidermal growth factor receptor; CAF: cancer-associated fibroblast.