fig1

Figure 1. (A) Eicosanoid rewiring and chronic inflammation; (B) Stromal and myeloid remodeling, barrier dysfunction and microbiota crosstalk; (C) Context-dependent PLA2G2A signaling circuitry. sPLA2-IIA: Group IIA secreted phospholipase A2; AA: arachidonic acid; COX-2: cyclooxygenase-2; LOX: lipoxygenase; PGE2: prostaglandin E2; LTB4: leukotriene B4; DC: dendritic cell; PD-1: programmed cell death protein 1; LAG-3: lymphocyte-activation gene 3; TIM-3: T-cell immunoglobulin and mucin domain-containing protein 3; IL-10: interleukin-10; CAF: cancer-associated fibroblast; HSPGs: heparan sulphate proteoglycans; ECM: extracellular matrix; EV: extracellular vesicle; IGF: insulin-like growth factor; CaMKII: calcium/calmodulin-dependent protein kinase II; ASK1: apoptosis signal-regulating kinase 1; ADH1B: alcohol dehydrogenase 1B; MFAP4: microfibril-associated protein 4; HIF-1α: hypoxia-inducible factor 1α; NF-κB: nuclear factor κB; C/EBPβ: CCAAT/enhancer-binding protein β; NFATC2: nuclear factor of activated T cells, cytoplasmic 2; STAT: signal transducer and activator of transcription; IFN-γ: interferon-gamma; T3: triiodothyronine; TRβ: thyroid hormone receptor β; PPAR: peroxisome proliferator-activated receptor; PLA2R1: phospholipase A2 receptor 1; EGFR: epidermal growth factor receptor; ERBB: ErbB family of receptor tyrosine kinases; HER: human epidermal growth factor receptor; ADAM: a disintegrin and metalloproteinase; HB-EGF: heparin-binding epidermal growth factor-like growth factor; FAK: focal adhesion kinase; PI3K-AKT: phosphoinositide 3-kinase-AKT pathway; MAPK: mitogen-activated protein kinase; ERK: extracellular signal-regulated kinase; PLCG: phospholipase C γ; EMT: epithelial-mesenchymal transition.