fig3

Figure 3. ADSL-mediated metabolic rewiring in PDAC. This figure highlights the non-canonical metabolic outputs of ADSL activity in PDAC. SAICAR–PKM2 signaling may reinforce glycolytic and transcriptional programs, whereas compartment-specific fumarate signaling may contribute to redox adaptation, epigenetic regulation, and innate immune modulation. These pathways position ADSL as a metabolic hub linking purine metabolism with adaptive tumor-cell behavior. ADSL: Adenylosuccinate lyase; PDAC: pancreatic ductal adenocarcinoma; SAICAR: succinylaminoimidazole carboxamide ribotide; PKM2: pyruvate kinase M2; AICAR: aminoimidazole carboxamide ribotide; AMP: adenosine monophosphate; NADH: reduced nicotinamide adenine dinucleotide; NADPH: reduced nicotinamide adenine dinucleotide phosphate; ATP: adenosine triphosphate.