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Figure 3. Cell survival rates after treatment with (A) diclofenac and (B) atazanavir; Comparison of cell viabilities after 72 h incubations with epirubicin, etoposide, and SN-38 in HepG2-EV and HepG2-UGT2B7 (C and E) or HepG2-UGT1A1 (D and F) cells with or without the UGT inhibitors diclofenac (diclo; C and E) or atazanavir (ata; D and F) at concentrations of 25 µM. Cell viability was assessed using the CellTiter-Glo® 2.0 Cell Viability Assay. Calculated IC₅₀ values were statistically compared using a two-tailed unpaired t-test with three biological replicates. Significance is denoted as follows: ns = not significant (P > 0.05), ^*P < 0.05, and ^**P < 0.01. UGT: Uridine diphosphate glucuronosyltransferase.