fig2

Figure 2. Dose response of parental (green) and 5-FU/LV-resistant (red) CRC cells to 5-FU/LV in (A) HCT116 (P = 0.0022), (B) LS174T (P = 0.0028), and (C) HCT15 (P < 0.0001) cells. Dose response to CF10/LV is shown in (D) HCT116 (P = 0.0337), (E) LS174T (P = 0.0009), and (F) HCT15 (P = 0.0112) parental (green) and 5-FU/LV-resistant (red) cells. IC50 values and resistance factors for each CRC cell line are summarized in Table 1. Figure preparation software is GraphPad Prism (RRID: SCR_002798). 5-FU: 5-Fluorouracil; LV: leucovorin; CRC: colorectal cancer.