fig2

MicroRNA-mediated autophagy regulation in thyroid cancer drug resistance

Figure 2. miRNAs and their targets involved in regulating autophagy and influencing drug sensitivity in thyroid cancer cells. miRNAs precisely modulate the expression of autophagy-related proteins, thus impacting drug resistance in thyroid cancer. miRNAs: MicroRNAs; BCR: B-cell receptor; PI3K: phosphoinositide 3-kinase; mTOR: mammalian target of rapamycin; ULK1 complex: unc-51 like autophagy activating kinase 1 complex; ATG: autophagy-related gene; Beclin-1: coiled-coil myosin-like BCL2-interacting protein; FOXP3: forkhead box protein P3; SPAG9: sperm-associated antigen 9; TGF-α: transforming growth factor-alpha; LC3I: cytosolic form of microtubule-associated protein 1A/1B-light chain 3; LC3II: phosphatidylethanolamine-conjugated form of microtubule-associated protein 1A/1B-light chain 3; FTC: follicular thyroid cancer; NMTC: non-medullary thyroid cancer; ATC: anaplastic thyroid cancer; PTC: papillary thyroid cancer.

Cancer Drug Resistance
ISSN 2578-532X (Online)

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