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Figure 2. miRNAs and their targets involved in regulating autophagy and influencing drug sensitivity in thyroid cancer cells. miRNAs precisely modulate the expression of autophagy-related proteins, thus impacting drug resistance in thyroid cancer. miRNAs: MicroRNAs; BCR: B-cell receptor; PI3K: phosphoinositide 3-kinase; mTOR: mammalian target of rapamycin; ULK1 complex: unc-51 like autophagy activating kinase 1 complex; ATG: autophagy-related gene; Beclin-1: coiled-coil myosin-like BCL2-interacting protein; FOXP3: forkhead box protein P3; SPAG9: sperm-associated antigen 9; TGF-α: transforming growth factor-alpha; LC3I: cytosolic form of microtubule-associated protein 1A/1B-light chain 3; LC3II: phosphatidylethanolamine-conjugated form of microtubule-associated protein 1A/1B-light chain 3; FTC: follicular thyroid cancer; NMTC: non-medullary thyroid cancer; ATC: anaplastic thyroid cancer; PTC: papillary thyroid cancer.