fig7

From: CDK4/6 and BET inhibitors synergistically suppress pancreatic tumor growth and epithelial-to-mesenchymal transition by regulating the GSK3β-mediated Wnt/β-catenin pathway

CDK4/6 and BET inhibitors synergistically suppress pancreatic tumor growth and epithelial-to-mesenchymal transition by regulating the GSK3β-mediated Wnt/β-catenin pathway

Figure 7. (A) Combined JQ1 and PD-0332991 significantly suppressed tumor growth in 60400 cells; (B) Changes in cell morphology before and after JQ1 monotherapy in 60400 cells. Scales bars, 100 μM; (C and D) Effects of PD-0332991, JQ1, and their combination on the migration of 60400 cells. Scales bars, 100 μM; (E) Combined treatment with JQ1 and PD-0332991 significantly suppressed tumor growth in 60400 cells. Data are presented as mean ± SEM from at least three independent experiments, with three randomly selected fields per experiment. ^*P < 0.05; ^**P < 0.01; ^****P < 0.0001; ns: not significant, Student’s t-test. SEM: Standard error of the mean.