fig3

Figure 3. TRAP1 affect mitochondrial morphology in Panc1 cells and derived CSCs. (A) Representative images of mitochondria of P cells, CSCs 2w, TRAP1-KO cells, and CSCs 2w TRAP1-KO analyzed by TEM. Scale bars are reported in the figure and correspond to 500 nm on the left panels and 200 nm on the right panels; (B) Histograms represent parameter analysis derived from TEM images of aspect ratio and area of mitochondria, and extension, width, junction dimension of mitochondrial cristae. Values are reported as fold change relative to P cells (± SE). Statistical legend: ^*P < 0.05 indicated condition vs. P cells, ^#condition vs. TRAP1-KO. Statistical methods: two-tailed Student’s t-test. CSCs: Cancer stem cells; TEM: transmission electron microscopy; SE: standard error.