fig1

Figure 1. Key drivers of T cell–mediated immune resistance in MPM. MPM: Malignant pleural mesothelioma; Treg: regulatory T cell; DC: dendritic cell; CD8⁺ T cell: cytotoxic T lymphocyte; MDSCs: myeloid-derived suppressor cells; ROS: reactive oxygen species; iNOS: inducible nitric oxide synthase; ASS1: argininosuccinate synthase 1; TGF-β: transforming growth factor beta; IL-10: interleukin-10; EMT: epithelial-mesenchymal transition; TIM-3: T-cell immunoglobulin and mucin-domain containing-3; LAG-3: lymphocyte-activation gene-3; TIGIT: T-cell immunoreceptor with Ig and ITIM domains; ICI: immune checkpoint inhibitor.