fig2

Figure 2. The mechanistic map linking resistance mechanisms to nano-interventions. MDSC: Myeloid-derived suppressor cell; TME: tumor microenvironment; PD-L1: programmed death-ligand 1; NPs: nanoparticles; HDL: high-density lipoprotein; IFN-γ: interferon-γ; JAK1/2: Janus kinase 1/2; STAT: signal transducer and activator of transcription; STING: stimulator of interferon genes; CDN: cyclic dinucleotide; PTEN: phosphatase and tensin homolog; PI3K: phosphoinositide 3-kinase; Akt: protein kinase B; mRNA: messenger RNA.