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Figure 1. RCC1 is highly expressed in colon cancer tissues. (A) IHC analysis of RCC1 expression in a tissue microarray; (B) Representative images showing RCC1 localization in the tumor and adjacent normal tissues. Scale bar: 200 μm; (C) Distribution of IHC scores with a 200% cutoff defining high vs. low expression. The histogram shows higher RCC1 levels in tumor tissues (chi-square test, P < 0.001); (D) RCC1 mRNA levels in colorectal tissues from the GEPIA2 database (One-way ANOVA, ^*P < 0.05); (E) Kaplan-Meier analysis of overall survival based on RCC1 expression (log-rank test, P < 0.05). RCC1: Regulator of chromosome condensation 1; IHC: immunohistochemical; COAD: colon adenocarcinom.