fig3

Identification of antibody-drug conjugate payloads that are substrates of ATP-binding cassette drug efflux transporters

Figure 3. P-gp overexpression confers resistance to treatment with MIRV. Three-day cytotoxicity assays were performed with MIRV as described in the Materials and Methods using the OVCAR8/NCI-ADR-RES pair (left) or the KB 3-1/KB 8-5-11 pair (right). Results from one of two independent experiments are shown. P-gp: P-glycoprotein; MIRV: mirvetuximab soravtansine.

Cancer Drug Resistance
ISSN 2578-532X (Online)

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