fig5

Targeting the hypoxia signaling pathway with nanomedicine to reverse immunotherapy resistance

Figure 5. (A) Schematic illustration of the injectable hydrogel and its role in T cell recruitment, reversal of T cell exhaustion, and MHC I-regulated immune escape in cancer immunotherapy; (B) In vivo inhibitory effects of the hydrogel on primary tumor and abscopal tumors. *P < 0.05, **P < 0.01, ***P < 0.001 [reproduced with permission from Zhang et al. (2022)[150]. Copyright 2022 John Wiley and Sons]. MHC I: Major histocompatibility complex class I.

Cancer Drug Resistance
ISSN 2578-532X (Online)

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