fig5

Figure 5. LN structure. The afferent lymphatic vessels transport antigens and APCs into the LN via the marginal sinus. The outer cortex contains the primary and secondary lymphoid follicles, including the germinal centers that support B cell activation and affinity maturation. The paracortical area (TCZ) is rich in T cells and HEVs, facilitating lymphocyte entry from the bloodstream. The medullary region, comprised of the medullary cords and sinuses, serves as a conduit for lymph and cellular egress through the efferent lymphatic vessel. Created in BioRender. Wang, L. (2025) https://BioRender.com/m0i16bb. LN: Lymph node; APCs: antigen-presenting cells; TCZ: T cell zone; HEVs: high endothelial venules.