fig1

Resistance signatures manifested in early drug response across cancer types and species

Figure 1. (A) Enrichment of the derived drug resistance signature gene at days 0, 3, 7, and 14 in the Oren et al. dataset[9]; (B) Distributions of raw AUCell scores of the resistance signature in each cluster across all cell lines; (C) Enrichment odds ratio of resistance-active cells in each cluster. Asterisks indicate significant odds ratio values (P < 0.05); (D) Standardized (z-score) mean AUCell scores of cancer hallmark pathways in each cluster across all cell lines. NES: Normalized Enrichment Score.

Cancer Drug Resistance
ISSN 2578-532X (Online)

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