fig4

From: KLF5 promotes tumor proliferation and oxaliplatin resistance via chromatin remodeling in KRAS-mutated colorectal cancer

Figure 4. KLF5 promotes proliferation and cell cycle progression in KRAS-mutant CRC. (A) Western blot validation of KLF5 overexpression and knockdown efficiency; (B and C) CCK-8 assays assessing the effects of KLF5 on cellular proliferation; (D and E) EdU incorporation assays demonstrating KLF5-mediated regulation of proliferative activity; (F) Colony formation assay evaluating KLF5-dependent clonogenic capacity; (G) Cell cycle analysis revealing KLF5-driven modulation of cell cycle distribution. Data represent the mean ± SD, Student’s t-test. ^*P < 0.05; ^**P < 0.01; ^***P < 0.001. KLF5: Krüppel-like factor 5; CRC: colorectal cancer; CCK-8: cell counting Kit-8; EdU: 5-ethynyl-2’-deoxyuridine; SD: standard deviation.