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From:  Cisplatin resistance in head and neck squamous cell carcinoma is linked to DNA damage response and cell cycle arrest transcriptomics rather than poor drug uptake
Cisplatin resistance in head and neck squamous cell carcinoma is linked to DNA damage response and cell cycle arrest transcriptomics rather than poor drug uptake

Figure 8. Kaplan-Meier plots of recurrence-free survival were generated for 292 patients. Patients were grouped according to the expression of individual genes (PP1R15A, GADD45G, FANCD2), the in vitro treatment-induced signature (mean of: CDKN1A, GADD45A, GADD45G, PP1R15A), and the baseline-high signature (mean of: FANCD2, OGG1, TP53). High expression of these genes or signatures was associated with worse outcomes. Each group comprised 146 patients.

Cancer Drug Resistance
ISSN 2578-532X (Online)
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