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Figure 1. Origins (left) and differentiation (right) of cancer-associated fibroblasts. MSC: Mesenchymal stem cell; EndMt: endothelial-to-mesenchymal transition; EMT: epithelial-to-mesenchymal transition; MMT: mesenchymal-to-mesenchymal transition; CAF: cancer-associated fibroblast; myCAFs: myofibroblastic cancer-associated fibroblasts; iCAFs: inflammatory cancer-associated fibroblasts; apCAFs: antigen-presenting cancer-associated fibroblasts^[8]. (Adopted from Herting et al., Cancer Metastasis Rev. 2021; doi:10.1007/s10555-021-09988-w).