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Figure 4. Cartoon showing diverse classes of phytochemicals investigated in vitro and in vivo for neuroblastoma chemoprevention, their mode of action and targeted cellular functions that dictate prevention of tumor progression, metastasis and disease evolution. Chemopreventive drugs target targets and/or signaling pathways, but largely the mode of action converge in defined sets of cellular/biological functions and conceptually supports the chemopreventive cocktail strategy for the development of effective molecular targeted maintenance therapy for neuroblastoma. Independent approaches displayed the systemic delivery feasibility, selective effect on tumor cells while sparing normal neural cells and neural stem cells, and excellent chemopreventive benefit of phytochemicals in the preclinical models of neuroblastoma.