REFERENCES
1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018;68:394-424.
2. Lötvall J, Hill AF, Hochberg F, Buzás EI, Di Vizio D, et al. Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles. J Extracell Vesicles 2014;3:26913.
3. Thery C, Witwer KW, Aikawa E, Alcaraz MJ, Anderson JD, et al. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles 2018;7:1535750.
4. Lane RE, Korbie D, Hill MM, Trau M. Extracellular vesicles as circulating cancer biomarkers: opportunities and challenges. Clin Transl Med 2018;7:14.
5. Zhang P, Samuel G, Crow J, Godwin A, Zeng Y. Molecular Assessment of Circulating Exosomes towards Liquid Biopsy Diagnosis of Ewing Sarcoma Family of Tumors. Transl Res 2018;201:136-153.
6. Schwich E, Rebmann V. The Inner and Outer Qualities of Extracellular Vesicles for Translational Purposes in Breast Cancer. Front Immunol 2018;9:584.
7. Fujita Y, Kuwano K, Ochiya T, Takeshita F. The Impact of Extracellular Vesicle-Encapsulated Circulating MicroRNAs in lung cancer research. Biomed Res Int 2014;2014:486413.
8. Verma M, Lam TK, Hebert E, Divi RL. Extracellular vesicles: potential applications in cancer diagnosis, prognosis, and epidemiology. BMC Clin Pathol 2015;15:6.
9. Anderson NL, Anderson NG. The human plasma proteome: history, character, and diagnostic prospects. Mol Cell Proteomics 2002;1:845-67.
10. Hortin GL, Sviridov D, Anderson NL. High-Abundance Polypeptides of the Human Plasma Proteome Comprising the Top 4 Logs of Polypeptide Abundance. Clin Chem 2008;54:1608-16.
11. Lobb RJ, Becker M, Wen Wen S, Wong CSF, Wiegmans AP, et al. Optimized exosome isolation protocol for cell culture supernatant and human plasma. J Extracell Vesicles 2015;4:27031.
12. Ludwig AK, De Miroschedji K, Doeppner TR, Börger V, Ruesing J, et al. Precipitation with polyethylene glycol followed by washing and pelleting by ultracentrifugation enriches extracellular vesicles from tissue culture supernatants in small and large scales. J Extracell Vesicles 2018;7:1528109.
13. Chen C, Skog J, Hsu CH, Lessard RT, Balaj L, et al. Microfluidic isolation and transcriptome analysis of serum microvesicles. Lab Chip 2010;10:505-11.
14. Davies RT, Kim J, Jang SC, Choi EJ, Gho YS, et al. Microfluidic filtration system to isolate extracellular vesicles from blood. Lab Chip 2012;12:5202-10.
15. Liang LG, Kong MQ, Zhou S, Sheng YF, Wang P, et al. An integrated double-filtration microfluidic device for isolation, enrichment and quantification of urinary extracellular vesicles for detection of bladder cancer. Sci Rep 2017;7:46224.
16. Wang Z, Wu HJ, Fine D, Schmulen J, Hu Y, et al. Ciliated micropillars for the microfluidic-based isolation of nanoscale lipid vesicles. Lab Chip 2013;13:2879-82.
17. Lee K, Shao H, Weissleder R, Lee H. Acoustic purification of extracellular microvesicles. ACS Nano 2015;9:2321-7.
18. Liu C, Guo J, Tian F, Yang N, Yan F, et al. Field-Free Isolation of Exosomes from Extracellular Vesicles by Microfluidic Viscoelastic Flows. ACS Nano 2017;11:6968-76.
19. Yuana Y, Levels J, Grootemaat A, Sturk A, Nieuwland R. Co-isolation of extracellular vesicles and high-density lipoproteins using density gradient ultracentrifugation. J Extracell Vesicles 2014;3:23262.
20. van Eijndhoven MAJ, Zijlstra JM, Groenewegen NJ, Drees EEE, van Niele S, et al. Plasma vesicle miRNAs for therapy response monitoring in Hodgkin lymphoma patients. JCI Insight 2017;1:e89631.
21. Karimi N, Cvjetkovic A, Jang SC, Crescitelli R, Hosseinpour Feizi MA, et al. Detailed analysis of the plasma extracellular vesicle proteome after separation from lipoproteins. Cell Mol Life Sci 2018;75:2873-86.
22. Sódar BW, Kittel Á, Pálóczi K, Vukman KV, Osteikoetxea X, et al. Low-density lipoprotein mimics blood plasma-derived exosomes and microvesicles during isolation and detection. Sci Rep 2016;6:24316.
23. Simonsen Jens B. What Are We Looking At? Extracellular Vesicles, Lipoproteins, or Both? Circ Res 2017;121:920-2.
24. de Gassart A, Géminard C, Février B, Raposo G, Vidal M. Lipid raft-associated protein sorting in exosomes. Blood 2003;102:4336-44.
25. Morelli AE, Larregina AT, Shufesky WJ, Sullivan ML, Stolz DB, et al. Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells. Blood 2004;104:3257-66.
26. Théry C, Boussac M, Véron P, Ricciardi-Castagnoli P, Raposo G, et al. Proteomic Analysis of Dendritic Cell-Derived Exosomes: A Secreted Subcellular Compartment Distinct from Apoptotic Vesicles. J Immunol 2001;166:7309-18.
27. Heijnen HFG, Schiel AE, Fijnheer R, Geuze HJ, Sixma JJ. Activated Platelets Release Two Types of Membrane Vesicles: Microvesicles by Surface Shedding and Exosomes Derived From Exocytosis of Multivesicular Bodies and -Granules. Blood 1999;94:3791-9.
28. Lai RC, Tan SS, Yeo RW, Choo AB, Reiner AT, et al. MSC secretes at least 3 EV types each with a unique permutation of membrane lipid, protein and RNA. J Extracell Vesicles 2016;5:29828.
29. Tan SS, Yin Y, Lee T, Lai RC, Yeo RWY, et al. Therapeutic MSC exosomes are derived from lipid raft microdomains in the plasma membrane AU - Tan, Soon Sim. J Extracell Vesicles 2013;2:22614.
30. Backlund PS, Aksamit RR, Unson CG, Goldsmith P, Spiegel AM, et al. Immunochemical and electrophoretic characterization of the major pertussis toxin substrate of the RAW264 macrophage cell line. Biochemistry 1988;27:2040-6.
31. Janko C, Jeremic I, Biermann M, Chaurio R, Schorn C, et al. Cooperative binding of Annexin A5 to phosphatidylserine on apoptotic cell membranes. Phys Biol 2013;10:065006.
32. G Peter M, Lingwood C. Apparent cooperativity in multivalent verotoxin-globotriaosyl ceramide binding: Kinetic and saturation binding studies with [125I]verotoxin. Biochim Biophys Acta 2000;1501:116-24.
33. Tan KH, Tan SS, Sze SK, Lee WKR, Ng MJ, et al. Plasma biomarker discovery in preeclampsia using a novel differential isolation technology for circulating extracellular vesicles. Am J Obstet Gynecol 2014;211:380.e1-3.
34. Reiner AT, Tan S, Agreiter C, Auer K, Bachmayr-Heyda A, et al. EV-Associated MMP9 in High-Grade Serous Ovarian Cancer Is Preferentially Localized to Annexin V-Binding EVs. Dis Markers 2017;2017:9653194.
35. Arraud N, Linares R, Tan S, Gounou C, Pasquet JM, et al. Extracellular vesicles from blood plasma: determination of their morphology, size, phenotype and concentration. J Thromb Haemost 2014;12:614-27.
36. Tan KH, Tan SS, Ng MJ, Tey WS, Sim WK, et al. Extracellular vesicles yield predictive pre-eclampsia biomarkers. J Extracell Vesicles 2017;6:1408390.
37. Rodrigues-Junior DM, Tan SS, de Souza Viana L, Carvalho AL, Lim SK, et al. A preliminary investigation of circulating extracellular vesicles and biomarker discovery associated with treatment response in head and neck squamous cell carcinoma. BMC Cancer 2019;19:373.
38. Reiner AT, Ferrer NG, Venugopalan P, Lai RC, Lim SK, et al. Magnetic nanoparticle-enhanced surface plasmon resonance biosensor for extracellular vesicle analysis. Analyst 2017;142:3913-21.
39. Kuziemko GM, Stroh M, Stevens RC. Cholera Toxin Binding Affinity and Specificity for Gangliosides Determined by Surface Plasmon Resonance. Biochemistry 1996;35:6375-84.
40. MacKenzie CR, Hirama T, Lee KK, Altman E, Young NM. Quantitative Analysis of Bacterial Toxin Affinity and Specificity for Glycolipid Receptors by Surface Plasmon Resonance. J Biol Chem 1997;272:5533-8.
41. Tait JF, Gibson D, Fujikawa K. Phospholipid binding properties of human placental anticoagulant protein-I, a member of the lipocortin family. J Biol Chem 1989;264:7944-9.
42. Andree H, Reutelingsperger C, Hauptmann R, Hemker HC, Hermens WT, et al. Binding of vascular anticoagulant alpha (VAC alpha) to planar phospholipid bilayers. J Biol Chem 1990;265:4923-8.
43. Landry JP, Ke Y, Yu GL, Zhu XD. Measuring affinity constants of 1450 monoclonal antibodies to peptide targets with a microarray-based label-free assay platform. J Immunol Methods 2015;417:86-96.
