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Figure 2. Exposure to embryonic stem cell (ESC)-microstrands overcomes chemotherapeutic drug resistance and reduces metastatic MDA-MB-231 cancer cell survival after drug treatment. A: MDA-MB-231 breast cancer cells (BCCs) were sensitive to the chemotherapeutic drugs Erlotinib and PNU 74654 when treated with 20 µmol/L for 30 min, followed by a 24-h recovery period. Simultaneous treatment with Erlotinib and PNU 74654 resulted in the largest decrease in cell viability suggesting that both pathways play a role in the metastatic phenotype; B: after being co-cultured with ESC-micorstrands, MDA-MB-231 BCCs exhibited significant reduction in cell viability after three cycles of treatment and recovery with both drugs at 20 µmol/L compared to non-co-cultured BCC control. ^*Statistical significance compared to untreated control (^#P < 0.05, ^**/##P < 0.01, and ^****/####P < 0.0001)