fig2

Figure 2. The principal and the two alternative androgen biosynthetic pathways: the canonical pathway is shown on white background, the backdoor pathway is shown on yellow background and the 5a-dione pathway on light blue background. In the squares, production of T and DHT in the development of PCa are shown. PCa: prostate cancer; T: testosterone; DHT: dihydrotestosterone; CYP17A1: cytochrome P450 17A1; HSD3B: 3b-hydroxysteroid dehydrogenase; HSD17B2/3/10: 17b-hydroxysteroid dehydrogenase type 2/3/10; SRD5A: steroid 5a-reductases; AKR1C1/2/3: aldo-keto reductase family 1, member 1/2/3; RDH5: retinol dehydrogenase type 5; AD: androstenedione